The Pirates of the Caribbean actor hates the attention he receives whenever he leaves the French property he shares with long-term partner Vanessa Paradis and their two children , Lily-Rose, 10, and Jack, seven, so shuts himself away from the "insanity" of modern life.
Depp - who also owns a private island in the Bahamas - said: "I don't leave the house anymore. If it isn't necessary I don't go anywhere. I stay at home.
"I'm adamant when it comes to that. I will never get used to it. If you do, you must be insane. I'm thankful for everything, but there's a limit to what a person can endure.
"I don't know how Brad Pitt and Angelina Jolie can bear that kind of life, because personally it's an issue for me."
The intensely private actor - who only feels truly relaxed when on his island- said his life is so insular, he learns everything from his children.
The 46-year-old actor explained to Germany's Tele 5: "Because I never leave the house I live outside society. But I'm a witness of my children's lives.
"I see how they're doing at school and how they treat their friends. My kids are a lot smarter than me. When I watch them I learn a lot. I don't think there's anything they could learn from me."
Teenage Depp dropped out of school to pursue a career in rock and roll music. Over the next few years, Depp fronted numerous garage bands - the most famous entitled The Kids, opened for Iggy Pop. Perhaps more importantly, the success of The Kids furnished Depp with a rising sense of popularity and accomplishment - ironically shot down by Iggy Pop himself during a back-stage confrontation. Determination and hope for stardom inspired the band to relocate to Los Angeles. Depp married by age 20 to Lori Allison, the band's make-up artist. As his band struggled among the competitive West-coast market, Depp (under suggestion from his wife) decided to try acting. An introduction to Nicolas Cage reluctantly persuaded Depp to audition. Depp's first film debut was in Wes Craven's major motion picture A Nightmare On Elm Street (1984). Unable to regain momentum, The Kids spilt-up soon after the movie's release and Depp diverged from his first love, music, to follow a life of acting. A small role in Platoon (1986) by Oliver Stone followed. Unwilling at first, Fox pursued Depp to star in a new series entitled 21, Jump Street. Although Depp felt this show "beneath him," it actually catapulted his success as an actor and turned him into a teenybopper idol.